Cart
sales@molnova.com
Home - Products - MAPK/ERK Signaling - MEK - Refametinib R enantiomer

Refametinib R enantiomer

CAS No. 923032-38-6

Refametinib R enantiomer( BAY 869766 R enantiomer | RDEA119 R enantiomer | RDEA-119 R enantiomer | BAY 86-9766 R enantiomer )

Catalog No. M16610 CAS No. 923032-38-6

The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 189 In Stock
10MG 279 In Stock
25MG 527 In Stock
50MG 702 In Stock
100MG 981 In Stock
500MG 1962 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Refametinib R enantiomer
  • Note
    Research use only, not for human use.
  • Brief Description
    The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor.
  • Description
    The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
  • In Vitro
    Refametinib R enantiomer is the R enantiomer of Refametinib . Refametinib R enantiomer is an inhibitor of MEK and is useful in treatment of cancer and other hyperproliferative diseases.
  • In Vivo
    ——
  • Synonyms
    BAY 869766 R enantiomer | RDEA119 R enantiomer | RDEA-119 R enantiomer | BAY 86-9766 R enantiomer
  • Pathway
    MAPK/ERK Signaling
  • Target
    MEK
  • Recptor
    MEK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    923032-38-6
  • Formula Weight
    572.3372
  • Molecular Formula
    C19H20F3IN2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
  • Chemical Name
    Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2R)-2,3-dihydroxypropyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Iverson C, et al. Cancer Res. 2009 Sep 1;69(17):6839-47. 2. Chang Q, et al. BMC Cancer. 2010 Sep 28;10:515. 3. Schmieder R, et al. Neoplasia. 2013 Oct;15(10):1161-71.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GSK-114

    GSK-114 is a potent, selective TNNI3K inhibitor with IC50 of 25 nM.

  • PD 198306

    PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1.

  • Tpl2-IN-34

    A potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.

Sign In Join Free